seqMeta: an R Package for meta analyzing region-based tests of rare DNA variants
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چکیده
Region-based tests are becoming a popular tool for analyzing rare genetic variants. In order for these tests to have adequate power, it is often necessary to meta-analyze information from multiple contributing studies, where consent restrictions make it difficult or impossible to share individual level data. We present the R package seqMeta for meta-analyzing region based tests, such as SKAT, SKAT-O, and burden tests, as well as single variant tests. The package can accommodate continuous, binary, and survival outcomes for unrelated individuals, and continuous outcomes for related individuals. We also provide convenient functions for conditional analyses and parallelization.
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seqMeta: an R Package for meta-analyzing region-based tests of rare DNA variants
Region-based tests are becoming a popular tool for analyzing rare genetic variants. In order for these tests to have adequate power, it is often necessary to meta-analyze information from multiple contributing studies, where consent restrictions make it difficult or impossible to share individual level data. We present the R package seqMeta for meta-analyzing region based tests, such as SKAT, S...
متن کاملseqMeta: an R Package for meta-analyzing region-based tests of rare DNA variants
Region-based tests are becoming a popular tool for analyzing rare genetic variants. In order for these tests to have adequate power, it is often necessary to meta-analyze information from multiple contributing studies, where consent restrictions make it difficult or impossible to share individual level data. We present the R package seqMeta for meta-analyzing region based tests, such as SKAT, S...
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Region-based tests are becoming a popular tool for analyzing rare genetic variants. In order for these tests to have adequate power, it is often necessary to meta-analyze information from multiple contributing cohorts, where consent restrictions make it difficult or impossible to share individual level data. We present the R package skatMeta for meta-analyzing region based tests, such as SKAT, ...
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